Regard de Kurt Ehrmann In olden times, crusaders ransacked a continent looking for the Holy Grail, and alchemists competed to rediscover the Philosophers’ Stone that could turn base metals into gold. In more recent centuries, humankind has labored to find a sweetener that can step in and take the place of sugar. All the substance must do is taste as good as sugar. The other requirement is that it have none of sugar’s less desirable intrinsic qualities, such as weight-boosting calories and or a chemical makeup that wreaks havoc on the human body. We just want an acceptable sugar substitute—is that too much to ask? Daniel Engberjan wrote, and the New York Times published, a monumental history of science’s attempt to answer this question.