Use of the targeted agent pacritinib significantly reduced the symptoms and burden of advanced myelofibrosis in patients, says a Mayo Clinic researcher who co-led PERSIST-1, the worldwide phase III clinical trial that tested the therapy. Specifically, pacritinib substantially reduced severe enlargement of the spleen, a typical feature of advanced myelofibrosis, in more than 20 percent of patients and alleviated debilitating side effects in more than 46 percent.
Category: Research
Sharp-eyed Alma spots a gigantic flare on famous red giant star
Super-sharp observations with the telescope Alma have revealed what seems to be a gigantic flare on the surface of Mira, one of the closest and most famous red giant stars in the sky. Activity like this in red giants – similar to what we see in the Sun — comes as a surprise to astronomers. The discovery could help explain how winds from giant stars make their contribution to our galaxy’s ecosystem.
Working together to build drought resiliency
As drought continues, and demand grows, researchers are looking to new models to improve the Rio Grande region’s drought resiliency.
New ‘designer carbon’ boosts battery performance
Scientists have created a new carbon material that significantly improves the performance of batteries and supercapacitors.
End European agreements with tobacco industry designed to curb smuggling, urge experts
The agreements drawn up between the European Union and the four major transnational tobacco companies, to crack down on cigarette smuggling and recoup lost tax revenues, are failing to meet their stated aims, concludes research.
Dry mouth: Acupuncture-like electrical nerve stimulation may help
Phase III results indicate that acupuncture-like, transcutaneous electrical nerve stimulation may be equally effective as pilocarpine, the current prescription medication in a pill, to treat radiation-induced xerostomia (dry mouth), according to a new study published.
Volunteers recruited to trial treatment to Hendra virus
A human trial of a treatment for the potentially deadly Hendra virus is about to begin in Brisbane.
Human Hendra drug, treatment not prevention
In a world first in the battle against the deadly Hendra virus, volunteers are being recruited to trial a human treatment for the virus.
Measuring kidney health could better predict heart disease risk
Simple measures of kidney function and damage may be just as good at predicting who is at risk for heart failure and death from heart attack and stroke as traditional tests of cholesterol levels and blood pressure, new research suggests.
Boosting Immunotherapy Against Brain Cancer
Boosting Immunotherapy Against Brain CancerResearchers used a tetanus booster to enhance the effects of an experimental immunotherapy against glioblastoma, a deadly type of brain cancer.
Interpreting Breast Biopsies
Interpreting Breast BiopsiesPathologists asked to interpret a difficult set of breast biopsy slides accurately made most diagnoses, but the results suggest strategies for future improvement.