Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research from the University of Eastern Finland. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. However, weight loss, induced by either obesity surgery or a very low-calorie diet, reverses these changes. The findings, presented by Dorota Kaminska, MSc, in her doctoral dissertation, increase our understanding of splicing dysregulations in obesity and can result in a new, more targeted treatment and more accurate diagnostics of metabolic disorders.
SOURCE: Medical Xpress – Medical research News – Read entire story here.
Related Posts
New ‘designer carbon’ boosts battery performance
Scientists have created a new carbon material that significantly improves the performance of batteries and supercapacitors.
Metformin found to reduce organ aging in male monkeys
Graphical abstract. Credit: Cell (2024). DOI: 10.1016/j.cell.2024.08.021 A team of biologists affiliated with multiple institutions […]
Controlling Brain Circuits in Mice
Controlling Brain Circuits in Mice Researchers developed a tool that can turn specific sets of neurons on and off in mice to affect behavior. The technology can help scientists study mental health and disorders.